Helpful, trusted answers from doctors: Dr. Seagraves on do anti inflammatory drugs suppress the immune system: This is true for most of the drugs used for an autoimmune disease. Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Prednisone is one of those drugs that are well known and studied but difficult to control. Think about it, this drug is used to essentially weaken your immune system throughout your body. Prednisone belongs to a family of drugs called corticosteroids that is often prescribed when a person's body does not produce enough natural steroid hormones. Prednisone also alters the functioning of the immune system and is used to treat several diseases in people who have normal corticosteroid I've been on prednisone for 15 months--began at 10mg and have weaned down to 5mg with 400mg plaquenil for the last 6 months. I have currently been experiencing what I think is a cold but the symptoms are not typical and i was wondering if this is what is meant by prednisone masking infections? prescribed prednisone and amoxicillin for flu? I was prescribed prednisone and amoxicillin for the flu. doctor did no tests. apparently they are both bad to take with the flu especially prednisone as it can spread the flu to other parts of my body and weaken my immune system? Immune deficiencies are also attributed to acquired infections or diseases that target the immune system, such as AIDS, while others, particularly primary immunodeficiency diseases, are often due to genetic abnormalities. RAYOS releases the action of prednisone about 4 hours after you take a tablet—so it can be conveniently timed to work when your disease is most active. Prednisone is similar to a compound that is made naturally in the body's adrenal gland, and may also be used to treat a variety of inflammatory conditions. All medicines are capable of producing side effects, and prednisone is no exception. Prednisone can cause allergic reactions (chest tightness, trouble breathing, rash, itching, facial swelling, hives or swelling in the mouth or throat), which warrant immediate medical attention.